Insulin Suppresses Plasma Concentration of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9
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چکیده
منابع مشابه
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor.
Growth of tumors and metastasis are processes known to require neovascularization. To ascertain the participation of the endogenous angiogenic inhibitor thrombospondin-1 (TSP1) in tumor progression, we generated mammary tumor-prone mice that either lack, or specifically overexpress, TSP1 in the mammary gland. Tumor burden and vasculature were significantly increased in TSP1-deficient animals, a...
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Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP) regulate each other, contributing to tumor progression. We have previously reported that MMP9 induces the release of tumor VEGF, promoting ascites formation in human ovarian carcinoma xenografts. The aim of this study was to investigate whether tumor-derived VEGF regulated the expression of gelatinase by the stroma, i...
متن کاملPnm-9: Serum and Peritoneal Fluid Level of Vascular Endothelial Growth Factor in Endometriosis
Background: Endometriosis is known as one of the most common disease in women of reproductive age. Due to importance role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell and different reported results for VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF ...
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BACKGROUND AND PURPOSE Human brain arteriovenous malformation tissue displays increased levels of vascular endothelial growth factor (VEGF) as well as matrix metalloproteinase (MMP)-9, a tissue protease associated with various intracerebral hemorrhage (ICH). We hypothesized that increased MMP-9 was associated with ICH induced by vascular endothelial growth factor hyperstimulation and that this ...
متن کاملa multicenter study on expressions of vascular endothelial growth factor, matrix metallopeptidase-9 and tissue inhibitor of metalloproteinase-2 in oral and maxillofacial squamous cell carcinoma
conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2003
ISSN: 0149-5992,1935-5548
DOI: 10.2337/diacare.26.12.3310